Journal of Liver Cancer

Jin Sil Seong

4 Articles

A Case of Hepatocellular Carcinoma in Young Age Younger than 20 Years Old: Joo Won Chung, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Kwang-Hyub Han, Chae Yoon Chon, Geung-kyu Ko, Jin Sil Seong, Jong Hee Chang, Do Young Kim; Journal of the Korean Liver Cancer Study Group. 2009;9(1):71-75. Published online June 30, 2009

Abstract PDF: Hepatocellular carcinoma (HCC) is very rare in young age. Most young patients tend to receive the evaluation only when they experience intractable or persistent symptoms. Therefore, HCC in young patients is often diagnosed at advanced stage and thus, young HCC patients have a worse prognosis than older HCC. However, because young HCC patients show well-preserved liver function than older HCC, they are tolerable to more aggressive treatments. We report a case of advanced HCC in 13-year and 8-month old male who has been a B-viral carrier. Despite the tumor size decreased after concurrent chemoradiation therapy, multiple lung and brain metastases developed. He underwent radiofrequency ablations on lung metastases and gamma-knife surgery on brain metastasis, and he has received systemic and intra-arterial chemotherapy. The screening and early diagnosis of HCC in young age is needed especially for B-viral carrier with a family history of HCC.

A Case of Curative Resection of Advanced Hepatocellular Carcinoma After Localized Concurrent Chemo-Radiation Therapy: Wonseok Kang, Ki Tae Yoon, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Chae Yoon Chon, Kyung Sik Kim, Young Nyun Park, Jin Sil Seong, Kwang Hyub Han; Journal of the Korean Liver Cancer Study Group. 2008;8(1):98-101. Published online June 30, 2008

Abstract PDF: Most patients with advanced hepatocellular carcinoma (HCC) are not suitable candidates for surgical treatment at the time of diagnosis because of poor liver function, extensive tumor involvement of the liver, vascular involvement, and/or intra/extrahepatic metastasis. We attempted localized concurrent chemo-radiation therapy (CCRT) followed by hepatic arterial infusion chemotherapy (HAIC) in patients having locally advanced HCC with vascular involvement and preserved hepatic function. We report a case of locally advanced HCC patient who became surgically resectable by downstaging after localized CCRT followed by HAIC. Localized CCRT was performed with a total radiation dose of 4,500 cGy (180 cGy × 25 times) and hepatic arterial infusion of 5-fluorouracil (5-FU, 500 mg/day) via implantable port system during the first and the last weeks of the radiotherapy. Following localized CCRT, the patient was scheduled to receive HAIC with 5-FU (500 mg/m2 for 5 hours, days 1～3) and cisplatin (60 mg/m2 for 2 hours, day 2) every 4 weeks. Marked contraction of HCC was noted on follow up computerized tomography (CT) and positron emission tomography (PET) after localized CCRT and HAIC, and subsequently surgical resection with curative aim was performed. The patient is in complete remission status without recurrence to date.

A Case of Localized Concurrent Chemo-radiation Therapy Using with Tomotherapy for Hilar Hepatocellular Carcinoma with Invasion of Bilateral Bile Duct: Ki Tae Yoon, Do Young Kim, Jin Sil Seong, Jun Yong Park, Jong Won Choi, Sang Hoon Ahn, Kwang-Hyub Han, Chae Yoon Chon; Journal of the Korean Liver Cancer Study Group. 2008;8(1):102-105. Published online June 30, 2008

Abstract PDF: Hepatocellular carcinoma (HCC) usually takes an intrahepatic spread via portal vein branches, and the incidence of portal vein invasion is reported to be 34～40% in surgical resected series. On the other hand, the rate of intrabiliary growth of HCC is rare, ranging from 2.3～13% in surgical and autopsy cases. Here, we report a case of the patient treated with localized concurrent chemo-radiation therapy (CCRT) for hilar HCC with invasion of bilateral bile duct. The tomotherapy was performed with a total radiation dose of 4,240 cGy (20 times, 212 cGy/time) on tumor bed and hepatic arterial infusion of 5-fluorouracil (1,000 mg/day, day 1～5 and day 16～20) and cisplatin (60 mg/m2, day 3 and day 18) was done via implantable port system during the radiotherapy. After that, tumor size and tumor marker was decreased and treatment response was achieved as partial response. CCRT is expected as one of the appropriated treatment options for inoperable HCC with bile duct invasion.

Radiotherapy of Hepatocellular Carcinoma invading Biliary Systerm: Jin Sil Seong; Journal of the Korean Liver Cancer Study Group. 2001;1(1):45-50. Published online June 30, 2001